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Ngày xuất bản: 14/12/2024
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DOI: https://doi.org/10.52714/dthu.14.5.2025.1530
Số xuất bản
Tập 14 Số 5 (2025): Chuyên san Khoa học Tự nhiên (Tiếng Anh)
Chuyên mục
Khoa học Tự nhiên (Tiếng Anh)
Trích dẫn bài báo
Nguyen, T. N. T., & Nguyen, T. N. H. (2024). Factors affecting the morphology and size of silica nanoparticles as drug delivery for cancer treatment. Tạp chí Khoa học Đại học Đồng Tháp, 14(5), 88-97. https://doi.org/10.52714/dthu.14.5.2025.1530

Factors affecting the morphology and size of silica nanoparticles as drug delivery for cancer treatment

Nguyen Thi Ngoc Tram1, , Nguyen Thi Ngoc Huyen1
1 School of Pharmacy, College of Medicine and Pharmacy, Tra Vinh University, Vietnam

Nội dung chính của bài viết

Tóm tắt

Currently, the use of nanoparticles as “carriers” to deliver drugs to the correct location has attracted the attention of scientists. Nano silica (SNs) is widely studied as material for biomedical applications. In this study, SNs particles were synthesized using the Stober method. The study investigated two factors affecting the morphology and particle size: reaction time and NH3 solution addition rate. Determining the characteristic properties of the material, methods used include transmission electron microscopy (TEM), X-ray diffraction (XRD), dynamic light scattering (DLS), and the N2 adsorption-desorption. SNs particles are spherical and highly homogeneous, with a 105.06 ± 0.74 nm size. The efficiency and loading capacity of Dox of SNs particles were 17.70 ± 0.52 % and 4.11 ± 0.11 %, respectively. The SNs/Dox drug carrier system has good potential for controlled drug release.

Từ khóa

Doxorubicin, drug loading efficiency, drug loading content, nano silica, particle size.

Chi tiết bài viết

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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