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24/03/2025
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Hội nghị Khoa học Tự nhiên Đồng bằng sông Cửu Long
Trích dẫn bài báo
Trương, T. P. T., & Phan , T. C. T. (2025). Khảo sát hoạt tính kháng oxy hóa và ức chế enzyme lipase tụy của cao chiết cây rau lang Ipomoea batatas L. Tạp chí Khoa học Đại học Đồng Tháp, 14(04S), 328-342. https://doi.org/10.52714/dthu.14.04S.2025.1596
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Khảo sát hoạt tính kháng oxy hóa và ức chế enzyme lipase tụy của cao chiết cây rau lang Ipomoea batatas L.
Nội dung chính của bài viết
Tóm tắt
Nghiên cứu thực hiện đánh giá hoạt tính kháng oxy hóa và khả năng ức chế enzyme lipase tụy của các cao chiết ethanol từ ba bộ phận (thân, lá và ngọn) của cây rau lang (Ipomoea batatas L.). Các cao chiết ethanol được định lượng hàm lượng polyphenol (TPC) và flavonoid (TFC), đồng thời đánh giá hoạt tính kháng oxy hóa thông qua các phương pháp DPPH, ABTS và năng lực khử sắt (RP). Hoạt tính ức chế enzyme lipase tụy được đánh giá in vitro bằng cơ chất p-nitrophenyl laurate, và in vivo trên chuột Mus musculus thông qua thử nghiệm hấp thu lipid. Cao chiết từ lá rau lang cho kết quả vượt trội so với thân và ngọn ở các chỉ số về hàm lượng chất và hoạt tính kháng oxy hóa (TPC: 279,4±1,83 mg GAE/g; TFC: 85,7±1,21 mg QE/g; IC₅₀ ABTS: 47,33±0,72 µg/mL; IC₅₀ DPPH: 80,86±3,13 µg/mL). Đặc biệt, cao lá cho thấy khả năng ức chế enzyme lipase mạnh nhất (IC₅₀ = 134,68±1,27 µg/mL), chỉ thấp hơn khoảng 2,3 lần so với thuốc đối chứng orlistat. Thử nghiệm in vivo xác nhận cao chiết lá làm giảm đáng kể nồng độ triglyceride huyết tương ở chuột sau khi uống nhũ tương lipid, tương đương với tác động của orlistat. Kết quả này chỉ ra rằng lá khoai lang là một nguồn thực vật tiềm năng giàu hợp chất polyphenol và flavonoid có hoạt tính kháng oxy hóa và ức chế enzyme tiêu hóa lipid khá tốt, cung cấp cơ sở khoa học cho việc phát triển các chế phẩm hỗ trợ kiểm soát béo phì và rối loạn chuyển hóa lipid.
Từ khóa
béo phì, cây rau lang, lipase tụy, kháng oxy hóa, triglyceride
Chi tiết bài viết
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Tài liệu tham khảo
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Birari, R. B., & Bhutani, K. K. (2007). Pancreatic lipase inhibitors from natural sources: Unexplored potential. Drug Discovery Today, 12(19-20), 879–889. https://doi.org/10.1016/j.drudis.2007.07.024
Cheng, C., Li, Z., Zhao, X., Liao, C., Quan, J., Bode, A.M., Cao, Y., & Luo, X. (2020). Natural alkaloid and polyphenol compounds targeting lipid metabolism: Treatment implications in metabolic diseases. European Journal of Pharmacology, 870, 172922. https://doi.org/10.1016/j.ejphar.2020.172922
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Doan, T. T., Nguyen, M. H., & Le, T. D. (2022). Evaluation of phytochemical composition and antioxidant activity of purple sweet potato (Ipomoea batatas L.) leaves grown in Vietnam. Vietnam Journal of Agricultural Sciences, 20(2), 45–53. https://doi.org/10.31817/vjas.2022.20.2.06
Heck, A. M., Yanovski, J. A., & Calis, K. A. (2000). Orlistat, a new lipase inhibitor for the management of obesity. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 20(3), 270–279. https://doi.org/10.1592/phco.20.4.270.34884
Hou, X.D., Qin, X.Y., Hou, J., Tang, H., & Ge, G.B. (2022). The potential of natural sources for pancreatic lipase inhibitors: a solution of the obesity crisis?. Expert Opinion on Drug Discovery, 17(12), 1295-1298. https://doi.org/10.1080/17460441.2023.2156499
Islam, M. S., Yoshimoto, M., Yahara, S., & Yamakawa, O. (2020). Antioxidant compounds from sweet potato (Ipomoea batatas L.) leaves. Food Chemistry, 91(1), 79–83. https://doi.org/10.1016/j.foodchem.2004.05.058
Jaradat, N., Zaıd, A.N., & Zaghal, E.Z. (2017). Anti-lipase activity for Portulaca oleracea, Urtica urens, Brassica napus and Lathyrus hierosolymitanus wild plants from Palestine. Marmara Pharmaceutical Journal, 21(4), 828-836. DOI: 10.12991/mpj.2017.9
Jeyadevi, R., Sivasudha, T., Ilango, K., & Karthikeyan, M. (2019). Antioxidant and free radical scavenging activity of Ipomoea staphylina Linn. Indian Journal of Pharmaceutical Sciences, 81(2), 342–348. https://doi.org/10.36468/pharmaceutical-sciences.513
Jung, Y., Lim, Y., & Kim, J. (2019). Sweet potato (Ipomoea batatas L.) leaf extract reduces adipogenesis and inflammation in 3T3-L1 adipocytes and high-fat diet-induced obese mice. Nutrition Research and Practice, 13(6), 507–514. https://doi.org/10.4162/nrp.2019.13.6.507
Kim, H. J., Kim, Y. J., & Kim, H. J. (2020). Antidiabetic and antiobesity effects of anthocyanin-rich purple sweet potato (Ipomoea batatas) extracts in high-fat diet-induced obese mice. Nutrition Research and Practice, 14(6), 507–516. https://doi.org/10.4162/nrp.2020.14.6.507
Koleva, I. I., van Beek, T. A., Linssen, J. P., de Groot, A., & Evstatieva, L. N. (2002). Screening of plant extracts for antioxidant activity: a comparative study on three testing methods. Phytochemical Analysis, 13(1), 8–17. https://doi.org/10.1002/pca.611
Li, M.M., Chen, Y.T., Ruan, J.C., Wang, W.J., Chen, J.G., & Zhang, Q.F. (2023). Structure-activity relationship of dietary flavonoids on pancreatic lipase. Current Research in Food Science, 6, 100424. https://doi.org/10.1016/j.crfs.2022.100424
Liu, T., Xie, Q., Zhang, M., Gu, J., Huang, D., & Cao, Q. (2024). Reclaiming Agriceuticals from Sweetpotato (Ipomoea batatas [L.] Lam.) By-Products. Foods, 13(8), 1180. https://doi.org/10.3390/foods13081180
Liu, T.T., Liu, X.T., Chen, Q.X., & Shi, Y. (2020). Lipase inhibitors for obesity: A review. Biomedicine & Pharmacotherapy, 128, 110314. https://doi.org/10.1016/j.biopha.2020.110314
Luo, S., Gill, H., Dias, D.A., Li, M., Hung, A., Nguyen, L.T., & Lenon, G.B. (2019). The inhibitory effects of an eight-herb formula (RCM-107) on pancreatic lipase: enzymatic, HPTLC profiling and in silico approaches. Heliyon, 5(9). DOI: 10.1016/j.heliyon.2019.e02453
Magalhães, B. R. R., Lopes, C. P., Silva, L. C., Nascimento, T. G., & Silva, M. S. (2015). Phenolic composition and antioxidant activity of leaves, stems and roots of medicinal plants from Brazil. Industrial Crops and Products, 77, 281–287. https://doi.org/10.1016/j.indcrop.2015.08.048
Magaña-Rodríguez, O.R., Ortega Pérez, L.G., Ayala-Ruiz, L.A., Piñon-Simental, J.S., Gallegos-Torres, O.F., & Rios Chavez, P. (2023). Inhibitory effects of edible and medicinal plant extracts on the enzymatic activity of pancreatic lipase. Journal of the Mexican Chemical Society, 67(3), 172-181. https://doi.org/10.29356/jmcs.v67i3.2004
McDougall, G.J., Kulkarni, N.N., & Stewart, D. (2008). Current developments on the inhibitory effects of berry polyphenols on digestive enzymes. Biofactors, 34(1), 73-80. https://doi.org/10.1002/biof.5520340108
Modanwal, S., Maurya, A.K., Mulpuru, V., & Mishra, N. (2025). Exploring flavonoid derivatives as potential pancreatic lipase inhibitors for obesity management: An in silico and in vitro study. Molecular Diversity, 29(3), 2499-2516. https://doi.org/10.1007/s11030-024-11005-5
Nikolaos, N., Wang, L.F., Tsimidou, M., & Zhang, H.Y. (2004). Estimation of scavenging sctivity of phenolic compounds using the ABTS•+ assay. Journal of Agricultural and Food Chemistry, 52(15), 4669-4674. https://doi.org/10.1021/jf0400056
Nguyen, T. T., & Lee, Y. H. (2021). Anti-obesity effects of polyphenol-rich plant extracts via inhibition of digestive enzymes and modulation of gut microbiota. Journal of Functional Foods, 77, 104326. https://doi.org/10.1016/j.jff.2020.104326
Nguyễn Kim Phi Phụng. (2007). Phương pháp cô lập hợp chất hữu cơ (Xuất bản lần thứ 1). Nhà xuất bản Đại học Quốc gia TP. Hồ Chí Minh. 528.
Olivas-Aguirre, F., Quintero-Vargas, J., Escobar-Puentes, A., & Wall-Medrano, A. (2024). Bioactive compounds and biological activities of sweet potato (Ipomoea batatas (L.) Lam.). In Bioactive Compounds in the Storage Organs of Plants. Cham: Springer Nature Switzerland, 877-900. https://doi.org/10.1007/978-3-031-44746-4_43
Oyaizu, M. (1986). Studies on products of browning reaction—Antioxidative activities of products of browning reaction prepared from glucosamine. Japanese Journal of Nutrition, 44(6), 307–315. https://doi.org/10.5264/eiyogakuzashi.44.307
Padma, R., Parvathy N.G., Renjith V., & Kalpana P.R. (2013). Quantitative estimation of tannins, phenols and antioxidant activity of methanolic extract of Imperata cylindrical. International Journal of Research in Pharmaceutical Sciences, 4(1), 73-77. file:///C:/Users/Admin/Downloads/tanninestimation.pdf
Padwal, R., & Majumdar, S. R. (2007). Drug treatments for obesity: Orlistat, sibutramine, and rimonabant. The Lancet, 369(9555), 71–77. https://doi.org/10.1016/S0140-6736(07)60033-6
Patil, S., Patil, M., Maheshwari, V.L., & Patil, R.H. (2022). Pancreatic lipase (PL) inhibitors from medicinal plants and their potential applications in the Management of Obesity. In Natural Products as Enzyme Inhibitors: An Industrial Perspective. Singapore: Springer Nature Singapore. 153-167. https://doi.org/10.1007/978-981-19-0932-0_7
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