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Date Published: 24/03/2025
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DOI: 10.52714/dthu.14.04S.2025.1586
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Vol. 14 No. 04S (2025): Special Issue of Mekong Delta Natural Science Conference
Section
Mekong Delta Natural Science Conference
How to Cite
Luong, T. K. N., & Nguyen, T. N. T. (2025). Investigation of antibacterial activities of wells-dawson polyoxometalates. Dong Thap University Journal of Science, 14(04S), 269-282. https://doi.org/10.52714/dthu.14.04S.2025.1586

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Investigation of antibacterial activities of wells-dawson polyoxometalates

Thi Kim Nga Luong1, , Thi Ngoc Tran Nguyen1
1 Chemistry Department, College of Natural Sciences, Can Tho University, Vietnam

Main Article Content

Abstract

The study was conducted to investigate the antibacterial activity of 8 Wells-Dawson polyoxometalate (POM) compounds including a-K6P2W18O62.14H20  and b-K6P2W18O62.19H2O (P2W18), K10[a2-K6P2W17O61].20H2O (P2W17), 
K15H[CeIV(a2-P2W17O61)2].25H2O (CeIVWD 1:2), K15H[Zr(a2-P2W17O61)2].25H2O (ZrWD 1:2), Na14[Zr4(P2W16O59)2 (m3-O)2(OH)2(H2O)4].57H2O (ZrWD 4:2), a2-K8P2W17O61(CoII.H2O).16H2O (CoWD 1:1), a2-K8P2W17O61(NiII.H2O).17H2O (NiWD 1:1) và a2-K8P2W17O61(CuII.H2O).16H2O (CuWD 1:1) against 5 bacterial strains including Escherichia coli, Salmonella spp., Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus. The antibacterial activity of all 8 Wells-Dawson POM compounds was examined by the agar well diffusion method and/or the 2-fold serial dilution method. The experimental results showed that for 3 bacterial species Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, all 8 WD-POM compounds showed antibacterial activity. Among them, P2W18 showed the best antibacterial activity against all 3 bacterial strains and the minimum inhibitory concentration (MIC) values ​​were determined to be 0.1875 mM, 6, 3, and 6 times lower than the MIC values ​​of the tetracycline positive control, respectively. For Escherichia coli, only P2W18showed antibacterial ability with an average inhibition zone of 7,33±0,58 mm, about 4 times smaller than that of the tetracycline positive control. For Salmonella spp., all 8 Wells-Dawson POM compounds did not show antibacterial ability.

Keywords

Antibacterial activity, Wells-Dawson polyoxometalates, agar well diffusion method, 2-fold continuous dilution method

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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