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Date Published: 10/08/2018
Online Published: 27/06/2023
Abstract Views: 135
Views PDF: 176
DOI: https://doi.org/10.52714/dthu.33.8.2018.613
Issue
No. 33 (2018): Part B - Natural Sciences
Section
Natural Sciences Issue
How to Cite
Tran, T. M., Nguyen, D. H. Y., & Dai, T. X. T. (2023). Evaluating toxicity and hepatoprotective ability of methanolic leaf extracts in HepG2 cell line. Dong Thap University Journal of Science, 33, 86-89. https://doi.org/10.52714/dthu.33.8.2018.613

Evaluating toxicity and hepatoprotective ability of methanolic leaf extracts in HepG2 cell line

Thanh Men Tran1, , Dinh Hai Yen Nguyen1, Thi Xuan Trang Dai1
1 Can Tho University

Main Article Content

Abstract

The study investigated the hepatoprotective ability of some methanolic leaf extracts from Premna serratifolia, Paederia lanuginosa and Paederia scandens in HepG2 cell line. The cytotoxic and hepatoprotective properties of methanolic extracts against damage induced by CCl4 were evaluated via measuring cell viability by the CCK8 kit. HepG2 cell line was damaged by CCl4 (1%) and treated with methanolic leaf extracts of Premna serratifolia, Paederia lanuginosa, Paederia scandens. The results showed that these leaf extracts were not poisonous on HepG2 cell at 500 µg/mL. In addition, it found that Premna serratifolia and Paederia lanuginosa methanolic leaf extracts had potent cytoprotective effects against CCl4 induced toxicity in HepG2 cell line.

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Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Keywords

Hepatoprotective, HepG2, Premna serratifolia L., Paederia lanuginosa, Paederia scandens

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