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Issue: 2026: Natural Sciences Issue - Online First
Section: Natural Sciences Issue (English)
DOI: 10.52714/dthu.ns.2933.1879
Date Published: 03/05/2026
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Le, T. B., Nguyen, M. N., Le, T. T., Le, T. T. X., Nguyen, T. P., Le, N. H. P., Do, H. P., Nguyen, T. N. A., To, T. H. T., Nguyen, V. H., & Nguyen, V. D. (2026). Chemical composition and antibacterial activity of Oldenlandia corymbosa L. Dong Thap University Journal of Science, Online First, 1-10. https://doi.org/10.52714/dthu.ns.2933.1879

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Chemical composition and antibacterial activity of Oldenlandia corymbosa L.

Thi Bach Le1, , Minh Nhut Nguyen1, Tan Tai Le1, Thi Thanh Xuan Le2, Tien Phong Nguyen3, Nguyen Hong Phuoc Le3, Hoang Phi Do3, Tran Nhat Anh Nguyen3, Thi Hoai Thu To3, Viiet Hoang Nguyen3, Van Dat Nguyen1
1 Department of Chemistry, College of Natural Sciences, Can Tho University, Vietnam
2 Faculty of Natural Sciences Teacher Education, School of Education, Dong Thap University, Cao Lanh 870000, Vietnam
3 Department of Health Science, College of Natural Sciences, Can Tho University, Vietnam

Main Article Content

Abstract

Oldenlandia corymbosa (family Rubiaceae) has been long used in traditional medicine for the treatment of various ailments such as fever, hepatitis, gastrointestinal disorders, cancer, and other inflammatory conditions. Numerous compounds isolated from this species have been reported to exhibit notable pharmacological activities, including anti-inflammatory, antioxidant, anticancer, immunomodulatory, and neuroprotective effects. In the present study, the antibacterial activity of different solvent fractions of O. corymbosa was evaluated to identify promising extracts for further phytochemical investigation. The ethyl acetate fraction showed the strongest inhibitions against Vibrio sp. and Aeromonas caviae, with particularly high inhibition against Vibrio sp. (86.78 ± 0.24 mm at 5.000 mg/mL). Chemical analysis of the ethyl acetate fraction was performed using silica gel column chromatography, and the chemical structures were elucidated by NMR spectroscopy through comparison with reference data, leading to the identification of three compounds: geniposide (1), rutin (2), and quercetin (3). These findings highlight the potential of O. corymbosa as a promising natural source of antibacterial agents.

Keywords

antbacterial activity, chemical constituents, Oldenlandia corymbosa L.

Article Details

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

References

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