Nghiên cứu thành phần hóa học và hoạt tính kháng khuẩn của lá cây dừa cạn (Catharanthus roseus (L.) G. Don)
Main Article Content
Abstract
Nghiên cứu này được thực hiện nhằm đánh giá sơ bộ hoạt tính kháng khuẩn của các cao chiết phân đoạn khác nhau từ lá cây Dừa cạn (Catharanthus roseus (L.) G. Don), qua đó lựa chọn cao chiết tiềm năng để tiếp tục nghiên cứu thành phần hóa học. Kết quả cho thấy cao chiết dichloromethane thể hiện hoạt tính kháng khuẩn đáng kể đối với hai loài vi khuẩn gây bệnh phổ biến trong nuôi trồng thủy sản là Vibrio sp. và Aeromonas caviae, đặc biệt hiệu quả đối với Vibrio sp. với đường kính vòng ức chế đạt 17,97±0,47 mm mm tại nồng độ 128 µg/mL. Phân tích thành phần hóa học của cao chiết dichloromethane bằng phương pháp phổ cộng hưởng từ hạt nhân (NMR), kết hợp với so sánh với dữ liệu từ các tài liệu tham khảo, đã xác định được ba hợp chất: apigenin (1), vindoline (2) và oleanolic acid (3). Các kết quả này khẳng định tiềm năng ứng dụng của lá cây Dừa cạn như một nguồn dược liệu tự nhiên với hoạt tính kháng khuẩn hiệu quả.
Keywords
antibacterial activity, Catharanthus roseus (L.) G. Don, chemical composition.
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